Estudio analítico de determinación mineralógica y de composición química de las cuentas de collar de calaíta y otras materias del yacimiento de Las Peñas (Quiruelas de Vidriales, Zamora)

Blanco Majado J., López Alonso M.A., Edo Benaiges M., Fernández Turiel J. L. Estudio analítico de determinación mineralógica y de composición química de las cuentas de collar de calaíta y otras materias del yacimiento de Las Peñas (Quiruelas de Vidriales, Zamora). Rubricatum, ISSN 1135-3791, 1995, 1: 227-237.[EN] We analyse a set of decorative elements, most of them made of calaíta, from an unpublished archaeological site in the province of Zamora, which could be dated to a Chalcolithic pre-Bell Beaker, dating from before 2500 a BC. These analyses are the first published for a deposit in the NW area of the Northern Meseta, both in terms of mineralogical and chemical composition.[ES] Analizamos un conjunto de elementos de adorno, la mayoría de ellos de calaíta, de un yacimiento arqueológico inédito de la provincia de Zamora, que se podría datar en un Calcolítico precampaniforme no anterior a 2500 a aC. Estos análisis son los primeros publicados para un yacimiento de la zona NW de la Meseta Norte, tanto por lo que se refiere a al composición mineralógica como a la química.Peer reviewe

Life-supporting human complement regulator decay accelerating factor transgenic pig liver xenograft maintains the metabolic function and coagulation in the nonhuman primate for up to 8 days

Background. It is not known whether the pig liver is capable of functioning efficiently when transplanted into a primate, neither is there experience in transplanting a liver from a transgenic pigs expressing the human complement regulator human complement regulator decay accelerating factor (h-DAF) into a baboon. The objective of this study was to determine whether the porcine liver would support the metabolic functions of non-human primates and to establish the effect of hDAF expression in the prevention of hyperacute rejection of porcine livers transplanted into primates. Methods. Five orthotopic liver xenotransplants from pig to baboon were carried out: three from unmodified pigs and two using livers from h-DAF transgenic pigs. Findings. The three control animals transplanted with livers from unmodified pigs survived for less than 12 hr. Baboons transplanted with livers from h-DAF transgenic pigs survived for 4 and 8 days. Hyperacute rejection was not detected in the baboons transplanted with hDAF transgenic pig livers; however, it was demonstrated in the three transplants from unmodified pigs. Baboons transplanted with livers from h-DAF transgenic pigs were extubated at postoperative day 1 and were awake and able to eat and drink. In the recipients of hDAF transgenic pig livers the clotting parameters reached nearly normal levels at day 2 after transplantation and remained normal up to the end of the experiments. In these hDAF liver recipients, porcine fibrinogen was first detected in the baboon plasma 2 hr postreperfusion, and was present up to the end of the experiments. One animal was euthanized at day 8 after development of sepsis and coagulopathy, the other animal arrested at day 4, after an episode of vomiting and aspiration. The postmortem examination of the hDAF transgenic liver xenografts did not demonstrate rejection. Interpretation. The livers from h-DAF transgenic pigs did not undergo hyperacute rejection after orthotopic xenotransplantation in baboons. When HAR is abrogated, the porcine liver maintains sufficient coagulation and protein levels in the baboon up to 8 days after OLT